Detailed view for MUL_4300

Basic information

TDR Targets ID: 954605
Mycobacterium ulcerans, 2-isopropylmalate synthase
Source Database / ID:  KEGG  

pI: 4.4748 | Length (AA): 566 | MW (Da): 61945 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00682   HMGL-like
PF08502   LeuA allosteric (dimerisation) domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0046912   transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer  
GO:0003852   2-isopropylmalate synthase activity  
GO:0003824   catalytic activity  
GO:0019752   carboxylic acid metabolic process  
GO:0009098   leucine biosynthetic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 565 3hq1 (A) 41 643 91.00 0 1 2.06773 -0.99

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132150)

Species Accession Gene Product
Candida albicans CaO19.13505   alpha-isopropylmalate synthase
Candida albicans CaO19.1375   leucine biosynthesis
Candida albicans CaO19.6086   alpha-isopropylmalate synthase
Candida albicans CaO19.8955   leucine biosynthesis
Mycobacterium leprae ML2324   2-ISOPROPYLMALATE SYNTHASE LEUA (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE)
Mycobacterium tuberculosis Rv3710   2-isopropylmalate synthase LeuA (alpha-isopropylmalate synthase) (alpha-IPM synthetase) (IPMS)
Mycobacterium ulcerans MUL_4300   2-isopropylmalate synthase
Saccharomyces cerevisiae YOR108W   2-isopropylmalate synthase LEU9
Saccharomyces cerevisiae YNL104C   2-isopropylmalate synthase LEU4

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_4300 (Mycobacterium ulcerans), 2-isopropylmalate synthase
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